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T-cadherin expression alternates with migrating neural crest cells in the trunk of the avian embryo

Ranscht, Barbara and Bronner-Fraser, Marianne (1991) T-cadherin expression alternates with migrating neural crest cells in the trunk of the avian embryo. Development, 111 (1). pp. 15-22. ISSN 0950-1991.

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Trunk neural crest cells and motor axons move in a segmental fashion through the rostral (anterior) half of each somitic sclerotome, avoiding the caudal (posterior) half. This metameric migration pattern is thought to be caused by molecular differences between the rostral and caudal portions of the somite. Here, we describe the distribution of T-cadherin (truncated-cadherin) during trunk neural crest cell migration. T-cadherin, a novel member of the cadherin family of cell adhesion molecules was selectively expressed in the caudal half of each sclerotome at all times examined. T-cadherin immunostaining appeared graded along the rostrocaudal axis, with increasing levels of reactivity in the caudal halves of progressively more mature (rostral) somites. The earliest T-cadherin expression was detected in a small population of cells in the caudal portion of the somite three segments rostral to last-formed somite. This initial T-cadherin expression was observed concomitant with the invasion of the first neural crest cells into the rostral portion of the same somite in stage 16 embryos. When neural crest cells were ablated surgically prior to their emigration from the neural tube, the pattern of T-cadherin immunoreactivity was unchanged compared to unoperated embryos, suggesting that the metameric T-cadherin distribution occurs independent of neural crest cell signals. This expression pattern is consistent with the possibility that T-cadherin plays a role in influencing the pattern of neural crest cell migration and in maintaining somite polarity.

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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1991 The Company of Biologists Limited. Accepted 28 September 1990. We thank Drs Andrew Lumsden and Scott Fraser for critical reading of the manuscript, and Kristin Bruk and Mary Flowers for excellent technical assistance. This work was supported by HD15527 and a Grant from the Muscular Dystrophy Association to M.B.-F. and by HD 25938 and Basil O'Connor Starter Scholar Research Award 5-752 from the March of Dimes Birth Defects Foundation to B.R. M.B.-F. is a Sloan Foundation Fellow and B.R. is a McKnight Scholar.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)HD-15527
Muscular Dystrophy AssociationUNSPECIFIED
U.S. Public Health Service (USPHS)HD-25938
March of Dimes Birth Defects Foundation5-752
Alfred P. Sloan FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Subject Keywords:trunk neural crest cell migration; cell adhesion molecules; chick embryos; somite; sclerotome
Issue or Number:1
Record Number:CaltechAUTHORS:20120418-145852839
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30178
Deposited On:19 Apr 2012 20:01
Last Modified:03 Oct 2019 03:48

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