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Differential intensity contrast swept source optical coherence tomography for human retinal vasculature visualization

Motaghiannezam, Reza and Fraser, Scott (2012) Differential intensity contrast swept source optical coherence tomography for human retinal vasculature visualization. In: Ophthalmic technologies XXII. Proceedings of SPIE . No.8209. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 82090O. ISBN 781331658. https://resolver.caltech.edu/CaltechAUTHORS:20120423-074920788

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Abstract

We demonstrate an intensity-based motion sensitive method, called differential logarithmic intensity variance (DLOGIV), for 3D microvasculature imaging and foveal avascular zone (FAZ) visualization in the in vivo human retina using swept source optical coherence tomog. (SS-OCT) at 1060 nm. A motion sensitive SS-OCT system was developed operating at 50,000 A-lines/s with 5.9 μm axial resoln., and used to collect 3D images over 4 mm^2 in a normal subject eye. Multiple B-scans were acquired at each individual slice through the retina and the variance of differences of logarithmic intensities as well as the differential phase variances (DPV) was calcd. to identify regions of motion (microvasculature). En face DLOGIV image were capable of capturing the microvasculature through depth with an equal performance compared to the DPV.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.907149DOIArticle
ORCID:
AuthorORCID
Fraser, Scott0000-0002-5377-0223
Additional Information:© 2012 SPIE. Online Mar 09, 2012. This work was supported in part by research from the California Institute for Regenerative Medicine (CIRM). The authors thank Carl Zeiss Meditec for providing the patient interface part of their Stratus OCT system.
Funders:
Funding AgencyGrant Number
California Institute for Regenerative Medicine (CIRM)UNSPECIFIED
Subject Keywords:Optical coherence tomography, Fourier Domain, Coherence imaging, Medical and biological imaging, Optical Coherence Angiography, Ophthalmology
Series Name:Proceedings of SPIE
Issue or Number:8209
Record Number:CaltechAUTHORS:20120423-074920788
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120423-074920788
Official Citation:Reza Motaghiannezam and Scott Fraser, "Differential intensity contrast swept source optical coherence tomography for human retinal vasculature visualization", Proc. SPIE 8209, 82090O (2012); http://dx.doi.org/10.1117/12.907149
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30250
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Apr 2012 17:48
Last Modified:03 Oct 2019 03:48

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