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Signal-processing machines at the postsynaptic density

Kennedy, Mary B. (2000) Signal-processing machines at the postsynaptic density. Science, 290 (5492). pp. 750-754. ISSN 0036-8075. doi:10.1126/science.290.5492.750.

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Dendrites of individual neurons in the vertebrate central nervous system are contacted by thousands of synaptic terminals relaying information about the environment. The postsynaptic membrane at each synaptic terminal is the first place where information is processed as it converges on the dendrite. At the postsynaptic membrane of excitatory synapses, neurotransmitter receptors are attached to large protein "signaling machines" that delicately regulate the strength of synaptic transmission. These machines are visible in the electron microscope and are called the postsynaptic density. By changing synaptic strength in response to neural activity, the postsynaptic density contributes to information processing and the formation of memories.

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Kennedy, Mary B.0000-0003-1369-0525
Additional Information:© 2000 American Association for the Advancement of Science. Supported by NIH grants NS17660 and NS28710 and by the John Douglas French Alzheimer's Foundation. I thank all the members of my laboratory for helpful discussions and for making our contribution to this research possible.
Funding AgencyGrant Number
John Douglas French Alzheimer's FoundationUNSPECIFIED
Issue or Number:5492
Record Number:CaltechAUTHORS:20120424-150158220
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30309
Deposited By: Melanie Stefan
Deposited On:24 Apr 2012 22:19
Last Modified:09 Nov 2021 19:45

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