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The postsynaptic density at glutamatergic synapses

Kennedy, Mary B. (1997) The postsynaptic density at glutamatergic synapses. Trends in Neurosciences, 20 (6). pp. 264-268. ISSN 0166-2236. doi:10.1016/S0166-2236(96)01033-8.

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The postsynaptic density (PSD) is a tiny, amorphous structure located beneath the postsynaptic membrane of synapses in the CNS. Until recently, the molecular composition and function of the PSD were mostly matters of speculation. With the advent of powerful new microchemical tools and molecular-genetic methods, three new classes of proteins have been identified in the PSD at glutamatergic synapses: the PSD-95 family, the NR2B subunit of the NMDA-type glutamate receptor, and densin-180. The PSD-95 family is involved in clustering of NMDA receptors. NR2B is phosphorylated by Ca^(2+)-calmodulin-dependent protein kinase type II, a prominent constituent of the PSD. Densin-180 might represent a new class of synaptic adhesion molecule. Study of these molecules is beginning to reveal the functional significance of the PSD.

Item Type:Article
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Kennedy, Mary B.0000-0003-1369-0525
Additional Information:© 1997 Elsevier Science Ltd. Available online 30 January 1998.
Subject Keywords:synaptic transmission; NMDA receptors; receptor clustering; PDZ domains; synaptic plasticity; signal transduction
Issue or Number:6
Record Number:CaltechAUTHORS:20120424-151012568
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Official Citation:Mary B. Kennedy, The postsynaptic density at glutamatergic synapses, Trends in Neurosciences, Volume 20, Issue 6, 1 June 1997, Pages 264-268, ISSN 0166-2236, 10.1016/S0166-2236(96)01033-8.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30314
Deposited By: Melanie Stefan
Deposited On:26 Apr 2012 14:29
Last Modified:09 Nov 2021 19:45

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