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Measuring shear strength of soft-tissue adhesives

Wang, Muzhou and Kornfield, Julia A. (2012) Measuring shear strength of soft-tissue adhesives. Journal of Biomedical Materials Research Part B, 100B (3). pp. 618-623. ISSN 1552-4973.

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A method for evaluating strength of adhesives for hydrogels and soft tissues is presented. Quantitative measurements of shear strength for applications in tissue engineering and biomedicine are performed in torsion using a rheometer. Small, disk shaped specimens of soft biological tissues and/or hydrogels (8 mm diameter, 1–2 mm thick) are mounted onto rheometer tools and then bonded together using the adhesive to be tested. The torsional loading geometry imposes simple shear without deforming the planar adhesive bond, in contrast to the lap-shear test. It retains the advantages of the napkin ring test while reducing artifacts due to cutting and handling soft specimens. The method is demonstrated by measuring the shear strength of two types of biomedical adhesives (cyanoacrylate and polyethylene glycol-based) between model hydrogels (gelatin) and tissues (corneal stroma and skin).

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Kornfield, Julia A.0000-0001-6746-8634
Additional Information:© 2012 Wiley Periodicals, Inc. Received 17 October 2010; revised 5 April 2011; accepted 2 June 2011. Published online 10 February 2012 in Wiley Online Library. The authors thank Dr. Michael Mackel, Dr. Matthew Mattson, and Dr. Ladan Foose for experimental suggestions and editing. We are grateful for funding from the Jacobs Institute for Molecular Engineering for Medicine at Caltech.
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Caltech Jacobs Institute for Molecular Engineering and MedicineUNSPECIFIED
Subject Keywords:tissue adhesion, hydrogel, stress, rheometer, torsion
Issue or Number:3
Record Number:CaltechAUTHORS:20120430-104835198
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Official Citation:Wang M, Kornfield JA. 2012. Measuring shear strength of soft-tissue adhesives. J Biomed Mater Res Part B 2012:100B:618–623.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30397
Deposited By: Ruth Sustaita
Deposited On:30 Apr 2012 18:09
Last Modified:03 Oct 2019 03:50

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