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In vivo human retinal and choroidal vasculature visualization using differential phase contrast swept source optical coherence tomography at 1060 nm

Motaghiannezam, Reza and Fraser, Scott (2012) In vivo human retinal and choroidal vasculature visualization using differential phase contrast swept source optical coherence tomography at 1060 nm. In: Optical coherence tomography and coherence domain optical methods in biomedicine XVI. Proceedings of SPIE. No.8213. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 821304. ISBN 783798221. http://resolver.caltech.edu/CaltechAUTHORS:20120504-134507608

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Abstract

A differential phase contrast (DPC) method is validated for in vivo human retinal and choroidal vasculature visualization using high-speed swept-source optical coherence tomography (SS-OCT) at 1060 nm. The vasculature was identified as regions of motion by creating differential phase variance (DPV) tomograms: multiple B-scans were collected of individual slices through the retina and the variance of the phase differences was calculated. DPV captured the small vessels and the meshwork of capillaries associated with the inner retina in en face images over 4 mm^2 in a normal subject. En face DPV images were capable of capturing the microvasculature and regions of motion through the inner retina and choroid.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.910991DOIArticle
ORCID:
AuthorORCID
Fraser, Scott0000-0002-5739-4026
Additional Information:© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). Online Jan 30, 2012. This work was supported in part by research from the California Institute for Regenerative Medicine (CIRM). The authors thank Carl Zeiss Meditec for providing the patient interface part of their Stratus OCT system.
Funders:
Funding AgencyGrant Number
California Institute for Regenerative Medicine (CIRM)UNSPECIFIED
Subject Keywords:Optical coherence tomography, Fourier Domain, Coherence imaging, Medical and biological imaging, Optical Coherence Angiography, Ophthalmology
Record Number:CaltechAUTHORS:20120504-134507608
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120504-134507608
Official Citation:Reza Motaghiannezam and Scott Fraser, "In vivo human retinal and choroidal vasculature visualization using differential phase contrast swept source optical coherence tomography at 1060 nm", Proc. SPIE 8213, 821304 (2012); http://dx.doi.org/10.1117/12.910991
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31309
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 May 2012 21:45
Last Modified:01 Jan 2016 03:59

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