A Caltech Library Service

Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior

Shim, Jongmin and Grosberg, Anna and Nawroth, Janna C. and Parker, Kevin Kit and Bertoldi, Katia (2012) Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior. Journal of Biomechanics, 45 (5). pp. 832-841. ISSN 0021-9290.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young's modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes.

Item Type:Article
Related URLs:
Additional Information:© 2011 Elsevier Ltd. Accepted 4 October 2011. Available online 9 January 2012. This work has been supported by the Harvard Materials Research Science and Engineering Center under NSF award number DMR-0820484(KB), DMR-0213805(KKP), and NIH grant 1 R01 HL079126(KKP). We are grateful to the Center of Nanoscale Systems at Harvard University for the use of their cleanroom facilities, to Alexander P. Nesmith for developing the brick patterned stamps, and to Harvard SEAS Academic Computing for their support.
Funding AgencyGrant Number
NSF Harvard Materials Research Science and Engineering CenterDMR-0820484
NSF Harvard Materials Research Science and Engineering CenterDMR-0213805
NIH1 R01 HL079126
Harvard SEAS Academic ComputingUNSPECIFIED
Subject Keywords:Cardiomyocytes; Cell alignment; Bio-hybrid thin film; Constitutive model; Finite element simulation; Pre-stretch; Isometric twitch stress
Issue or Number:5
Record Number:CaltechAUTHORS:20120504-140746045
Persistent URL:
Official Citation:Jongmin Shim, Anna Grosberg, Janna C. Nawroth, Kevin Kit Parker, Katia Bertoldi, Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior, Journal of Biomechanics, Volume 45, Issue 5, 15 March 2012, Pages 832-841, ISSN 0021-9290, 10.1016/j.jbiomech.2011.11.024.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31310
Deposited By: Tony Diaz
Deposited On:07 May 2012 21:40
Last Modified:03 Oct 2019 03:50

Repository Staff Only: item control page