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Decision value computation in DLPFC and VMPFC adjusts to the available decision time

Sokol-Hessner, Peter and Hutcherson, Cendri and Hare, Todd and Rangel, Antonio (2012) Decision value computation in DLPFC and VMPFC adjusts to the available decision time. European Journal of Neuroscience, 35 (7). pp. 1065-1074. ISSN 0953-816X. PMCID PMC3325500. https://resolver.caltech.edu/CaltechAUTHORS:20120507-114205337

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Abstract

It is increasingly clear that simple decisions are made by computing decision values for the options under consideration, and then comparing these values to make a choice. Computational models of this process suggest that it involves the accumulation of information over time, but little is known about the temporal course of valuation in the brain. To examine this, we manipulated the available decision time and observed the consequences in the brain and behavioral correlates of choice. Participants were scanned with functional magnetic resonance imaging while they chose to eat or not eat basic food items, in two conditions differing in the amount of time provided for choice. After identifying valuation-related regions with unbiased whole-brain general linear models, we analyzed two regions of interest: ventromedial prefrontal cortex (VMPFC) and dorsolateral prefrontal cortex (DLPFC). Finite impulse response models of the upsampled estimated neural activity from those regions allowed us to examine the onset, duration and termination of decision value signals, and to compare across regions. We found evidence for the immediate onset of value computation in both regions, but an extended duration with longer decision time. However, this was not accompanied by behavioral changes in either the accuracy or determinants of choice. Finally, there was modest evidence that DLPFC computation correlated with, but lagged behind, VMPFC computation, suggesting the sharing of information across these regions. These findings have important implications for models of decision value computation and choice.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.1460-9568.2012.08076.x DOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2012.08076.x/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325500/PubMed CentralArticle
ORCID:
AuthorORCID
Hutcherson, Cendri0000-0002-4441-4809
Additional Information:© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. Received 25 November 2011, revised 9 February 2012, accepted 12 February 2012. Article first published online: 4 Apr 2012. This research was supported by the NSF (SES-0851408, SES-0926544, SES-0850840), NIH (R01 AA018736), the Betty and Gordon Moore Foundation, and the Lipper Foundation to A.R.
Funders:
Funding AgencyGrant Number
NSFSES-0851408
NSFSES-0926544
NSFSES-0850840
NIHR01 AA18736
Gordon and Betty Moore FoundationUNSPECIFIED
Lipper FoundationUNSPECIFIED
Subject Keywords:choice, finite impulse response, fMRI, hemodynamic deconvolution, information accumulation
Issue or Number:7
PubMed Central ID:PMC3325500
Record Number:CaltechAUTHORS:20120507-114205337
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120507-114205337
Official Citation:Sokol-Hessner, P., Hutcherson, C., Hare, T. and Rangel, A. (2012), Decision value computation in DLPFC and VMPFC adjusts to the available decision time. European Journal of Neuroscience, 35: 1065–1074. doi: 10.1111/j.1460-9568.2012.08076.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31336
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:08 May 2012 15:08
Last Modified:09 Mar 2020 13:18

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