A Caltech Library Service

Diversity of the G-protein family: sequences from five additional α subunits in the mouse

Strathmann, Michael and Wilkie, Thomas M. and Simon, Melvin I. (1989) Diversity of the G-protein family: sequences from five additional α subunits in the mouse. Proceedings of the National Academy of Sciences of the United States of America, 86 (19). pp. 7407-7409. ISSN 0027-8424. PMCID PMC298071. doi:10.1073/pnas.86.19.7407.

PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Biochemical analysis has revealed a number of guanine nucleotide-binding regulatory proteins (G proteins) that mediate signal transduction in mammalian systems. Characterization of their cDNAs uncovered a family of proteins with regions of highly conserved amino acid sequence. To examine the extent of diversity of the G protein family, we used the polymerase chain reaction to detect additional gene products in mouse brain and spermatid RNA that share these conserved regions. Sequences corresponding to six of the eight known G protein alpha subunits were obtained. In addition, we found sequences corresponding to five newly discovered alpha subunits. Our results suggest that the complexity of the G protein family is much greater than previously suspected.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Additional Information:© 1989 National Academy of Sciences. Contributed by Melvin I. Simon, July 11, 1989. We thank Ryn Miake-Lye, Gregg Gundersen, and Anthony Bellvd for RNA; Narasimhan Gautam for valuable discussions, George Komatsoulis for computer analysis; and Mike Lochrie and Andy Pakula for critical reading of the manuscript. This work was supported by the National Science Foundation and the National Institutes of Health.
Funding AgencyGrant Number
Issue or Number:19
PubMed Central ID:PMC298071
Record Number:CaltechAUTHORS:20120510-091658522
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31402
Deposited On:10 May 2012 21:23
Last Modified:09 Nov 2021 19:52

Repository Staff Only: item control page