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Differential phase-contrast, swept-source optical coherence tomography at 1060 nm for in vivo human retinal and choroidal vasculature visualization

Motaghiannezam, S. M. Reza and Koos, David and Fraser, Scott E. (2012) Differential phase-contrast, swept-source optical coherence tomography at 1060 nm for in vivo human retinal and choroidal vasculature visualization. Journal of Biomedical Optics, 17 (2). Art. No. 026011. ISSN 1083-3668. https://resolver.caltech.edu/CaltechAUTHORS:20120515-154003951

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Abstract

Human retinal and choroidal vasculature was visualized by a differential phase-contrast (DPC) method using high-speed, swept-source optical coherence tomography (SS-OCT) at 1060 nm. The vasculature was recognized as regions of motion by creating differential phase-variance (DPV) tomograms: multiple B-scans of individual slices through the retina were collected and the variance of the phase differences was calculated. DPV captured the small vessels and the meshwork of capillaries associated with the inner retina in en-face images over 4  mm^2. The swept-source laser at 1060 nm offered the needed phase sensitivity to perform DPV and generated en-face images that capture motion in the inner choroidal layer exceeding the capabilities of previous spectrometer-based instruments. In comparison with the power Doppler phase-shift method, DPV provided better visualization of the foveal avascular zone in en-face images.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.17.2.026011DOIArticle
http://spiedigitallibrary.org/jbo/resource/1/jbopfo/v17/i2/p026011_s1PublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 2012 Society of Photo-Optical Instrumentation Engineers. Paper 11524 received Sep. 20, 2011; revised manuscript received Dec. 16, 2011; accepted for publication Dec. 20, 2011; published online Mar. 1, 2012. This work was supported in part by research from the California Institute for Regenerative Medicine (CIRM). The authors thank Carl Zeiss Meditec for providing the patient interface part of the OCT system.
Funders:
Funding AgencyGrant Number
California Institute for Regenerative Medicine (CIRM)UNSPECIFIED
Subject Keywords:retinal optical coherence tomography; choroidal optical coherence tomography; swept-source optical coherence tomography; optical microangiography; phase-sensitive imaging; 1-μm light source
Issue or Number:2
Record Number:CaltechAUTHORS:20120515-154003951
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120515-154003951
Official Citation:S. M. Reza Motaghiannezam, David Koos and Scott E. Fraser, "Differential phase-contrast, swept-source optical coherence tomography at 1060 nm for in vivo human retinal and choroidal vasculature visualization", J. Biomed. Opt. 17, 026011 (Mar 01, 2012); http://dx.doi.org/10.1117/1.JBO.17.2.026011
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31485
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 May 2012 20:47
Last Modified:03 Oct 2019 03:52

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