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The complex process of GETting tail-anchored membrane proteins to the ER

Chartron, Justin W. and Clemons, William M., Jr. and Suloway, Christian J. M. (2012) The complex process of GETting tail-anchored membrane proteins to the ER. Current Opinion in Structural Biology, 22 (2). pp. 217-224. ISSN 0959-440X. PMCID PMC3359790.

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Biosynthesis of membrane proteins requires that hydrophobic transmembrane (TM) regions be shielded from the cytoplasm while being directed to the correct membrane. Tail-anchored (TA) membrane proteins, characterized by a single C-terminal TM, pose an additional level of complexity because they must be post-translationally targeted. In eukaryotes, the GET pathway shuttles TA-proteins to the endoplasmic reticulum. The key proteins required in yeast (Sgt2 and Get1–5) have been under extensive structural and biochemical investigation during recent years. The central protein Get3 utilizes nucleotide linked conformational changes to facilitate substrate loading and targeting. Here we analyze this complex process from a structural perspective, as understood in yeast, and further postulate on similar pathways in other domains of life.

Item Type:Article
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URLURL TypeDescription DOIArticle CentralArticle
Clemons, William M., Jr.0000-0002-0021-889X
Additional Information:© 2012 Elsevier Ltd. Available online 21 March 2012. We are grateful to Harry Gristick, Meera Rao, Doug Rees and Michael Rome for commenting on the manuscript. Research in the Clemons lab is funded by an R01 from the National Institutes of Health grant GM097572.
Funding AgencyGrant Number
NIHR01 GM097572
Issue or Number:2
PubMed Central ID:PMC3359790
Record Number:CaltechAUTHORS:20120522-110049963
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Official Citation:Justin W Chartron, William M Clemons Jr., Christian JM Suloway, The complex process of GETting tail-anchored membrane proteins to the ER, Current Opinion in Structural Biology, Volume 22, Issue 2, April 2012, Pages 217-224, ISSN 0959-440X, 10.1016/
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31591
Deposited By: Tony Diaz
Deposited On:22 May 2012 21:27
Last Modified:03 Oct 2019 03:53

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