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Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane

Chen, Mike M. Y. and Coelho, Pedro S. and Arnold, Frances H. (2012) Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane. Advanced Synthesis and Catalysis, 354 (6). pp. 964-968. ISSN 1615-4150. doi:10.1002/adsc.201100833.

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Terminal oxidant-supported P450 reactions alleviate the need for substrate binding to initiate catalysis by chemically generating “compound I.” This allows investigation of the innate substrate range of the enzyme active site. Using iodosylbenzene as the oxidant, CYP153A6, a medium-chain terminal alkane hydroxylase, exhibits methanol formation in the presence of methane demonstrating that P450-mediated methane hydroxylation is possible.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. Received: October 25, 2011; Published online: April 4, 2012. This work was supported by the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Science, U.S. Department of Energy grant DE-FG02-06ER15762. We thank Dr. Nathan Dalleska for assistance with gas chromatography and Dr. Jared Lewis for helpful discussion.
Funding AgencyGrant Number
Department of Energy (DOE)DE-FG02-06ER15762
Subject Keywords:C-H activation; compound I; enzyme catalysis; metalloenzymes; methane oxidation
Issue or Number:6
Record Number:CaltechAUTHORS:20120522-134624475
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Official Citation:Chen, M. M., Coelho, P. S. and Arnold, F. H. (2012), Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane. Adv. Synth. Catal., 354: 964–968. doi: 10.1002/adsc.201100833
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31599
Deposited By: Ruth Sustaita
Deposited On:22 May 2012 21:26
Last Modified:09 Nov 2021 19:56

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