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How important is the corpus callosum in resting-state networks?

Paul, Lynn K. and Tyszka, J. Michael (2012) How important is the corpus callosum in resting-state networks? Future Neurology, 7 (3). pp. 231-234. ISSN 1748-6971. doi:10.2217/fnl.12.17.

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The human brain appears to have a reproducible set of intrinsic functional networks. Each network consists of several brain regions whose activity patterns are temporally correlated with one another when the individual is not doing any particular task. Most of these networks are bilaterally symmetric, therefore requiring some form of interhemispheric coordination. Evidence from individuals who have had a callosotomy and individuals born with callosal agenesis suggests that although the corpus callosum is heavily involved in the resting networks of healthy human brains, typical bilateral resting-state networks can also emerge in the absence of callosal connections. Understanding how and why this is possible will provide important insights into development and plasticity of brain function.

Item Type:Article
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URLURL TypeDescription
Paul, Lynn K.0000-0002-3128-8313
Tyszka, J. Michael0000-0001-9342-9014
Additional Information:© 2012 Future Medicine Ltd. The authors would like to thank R Adolphs for his continued encouragement and support of their research on callosal agenesis and his comments on this Editorial. The Caltech Corpus Callosum research projects are supported by the National Alliance for Research on Schizophrenia and Depression (2009 Young Investigator Award), the BIAL Foundation (2011 Bursary) and the National Institute of Mental Health (5 R01 MH080721). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Funding AgencyGrant Number
National Alliance for Research on Schizophrenia and DepressionUNSPECIFIED
NIH5 R01 MH080721
Subject Keywords:agenesis; BOLD; brain; connectivity; corpus callosum; fMRI; human; interhemispheric; resting state; white matter
Issue or Number:3
Record Number:CaltechAUTHORS:20120529-084417409
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31668
Deposited By: Tony Diaz
Deposited On:08 Jun 2012 18:24
Last Modified:09 Nov 2021 19:57

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