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Allurin, an Amphibian Sperm Chemoattractant Having implications for Mammalian Sperm Physiology

Burnett, Lindsey A. and Washburn, Catherine A. and Sugiyama, Hitoshi and Xiang, Xueyu and Olson, John H. and Al-Anzi, Bader and Bieber, Allan L. and Chandler, Douglas E. (2012) Allurin, an Amphibian Sperm Chemoattractant Having implications for Mammalian Sperm Physiology. International Review of Cell and Molecular Biology (295). pp. 1-61. ISSN 1937-6448. https://resolver.caltech.edu/CaltechAUTHORS:20120529-103502250

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Abstract

Eggs of many species are surrounded by extracellular coats that emit ligands to which conspecific sperm respond by undergoing chemotaxis and changes in metabolism, motility, and acrosomal status in preparation for fertilization. Here we review methods used to measure sperm chemotaxis and focus on recent studies of allurin, a 21-kDa protein belonging to the Cysteine-RIch Secretory Protein (CRISP) family that has chemoattraction activity for both amphibian and mammalian sperm. Allurin is unique in being the first extensively characterized Crisp protein found in the female reproductive tract and is the product of a newly discovered amphibian gene within a gene cluster that has been largely conserved in mammals. Study of its expression, function, and tertiary structure could lead to new insights in the role of Crisp proteins in sperm physiology.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/B978-0-12-394306-4.00007-1DOIArticle
http://www.sciencedirect.com/science/article/pii/B9780123943064000071PublisherArticle
Additional Information:© 2012 Elsevier Inc. Available online 23 March 2012. The contributions of Dr. Barry Bonnell, Dr. Tillman Ziegert, and Dr. Alan Rawls to this work are gratefully acknowledged. We thank the W.M. Keck Bioimaging Laboratory for provision of much of the microscopy instrumentation used in our studies. These studies were supported by the National Science Foundation under grants IBN-9807862, IBN-0130001, and IOS-0615435.
Funders:
Funding AgencyGrant Number
NSFIBN-9807862
NSFIBN-0130001
NSFIOS-0615435
Subject Keywords:Crisp proteins, Sperm chemoattraction, Fertilization, Xenopus laevis, Egg jelly
Series Name:International Review of Cell and Molecular Biology
Issue or Number:295
Record Number:CaltechAUTHORS:20120529-103502250
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120529-103502250
Official Citation:Lindsey A. Burnett, Catherine A. Washburn, Hitoshi Sugiyama, Xueyu Xiang, John H. Olson, Bader Al-Anzi, Allan L. Bieber, Douglas E. Chandler, Chapter one - Allurin, an Amphibian Sperm Chemoattractant Having Implications for Mammalian Sperm Physiology, In: Kwang W. Jeon, Editor(s), International Review of Cell and Molecular Biology, Academic Press, 2012, Volume 295, Pages 1-61, ISSN 1937-6448, ISBN 9780123943064, 10.1016/B978-0-12-394306-4.00007-1. (http://www.sciencedirect.com/science/article/pii/B9780123943064000071)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31674
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:29 May 2012 18:10
Last Modified:03 Oct 2019 03:53

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