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Photophobe (Ppb), a Drosophila mutant with a reversed sign of phototaxis; the mutation shows an allele-specific interaction with sevenless

Ballinger, Dennis G. and Benzer, Seymour (1988) Photophobe (Ppb), a Drosophila mutant with a reversed sign of phototaxis; the mutation shows an allele-specific interaction with sevenless. Proceedings of the National Academy of Sciences of the United States of America, 85 (11). pp. 3960-3964. ISSN 0027-8424.

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We have isolated a dominant behavioral mutation, Photophobe (Ppb), on the second chromosome of Drosophila melanogaster. Although wild-type flies are attracted towards green light, flies homozygous for the Ppb mutation avoid it over an intensity range of six logarithms. Ppb interacts in a dominant way with mutations in the sevenless (sev) gene, an X-chromosomal gene necessary for photoreceptor cell 7 differentiation in the Drosophila retina. Specific alleles of sev alter the Ppb behavioral phenotype; of eight sev alleles tested, two alleles enhanced the negative phototaxis of Ppb, whereas six alleles had the opposite effect. In no mutant combination of Ppb and sev was photoreceptor cell 7 restored. These data show that the sev gene, in addition to its role in the differentiation of photoreceptor cell 7, plays a role along with Ppb in a common visual information-processing pathway.

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Additional Information:© 1988 National Academy of Sciences. Contributed by Seymour Benzer, February 18, 1988. We thank John Pollock for his help in calibrating the light intensities and Sasha Kamb, Paul Sternberg, Bruce Rabin, S. L. Zipursky, and the members of our laboratory for helpful discussions and comments on the manuscript. D.G.B. was supported by a Myron A. Bantrell Postdoctoral Fellowship and one from the National Institutes of Health (5 F32 EY 05742-02). The work was supported by a grant from the National Science Foundation (DCB-8409366) to S.B. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funding AgencyGrant Number
Myron A. Bantrell Postdoctoral FellowshipUNSPECIFIED
NIH5 F32 EY 05742-02
Subject Keywords:behavioral genetics; suppressor mutations; Drosophila melanogaster; photophobia; color-choice phototaxis
Record Number:CaltechAUTHORS:20120531-095103223
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31739
Deposited By: Jason Perez
Deposited On:31 May 2012 17:14
Last Modified:23 Aug 2016 00:11

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