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The antigenic index: a novel algorithm for predicting antigenic determinants

Jameson, B. A. and Wolf, H. (1988) The antigenic index: a novel algorithm for predicting antigenic determinants. Computer Applications in the Biosciences (CABIOS), 4 (1). pp. 181-186. ISSN 0266-7061.

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In this paper, we introduce a computer algorithm which can be used to predict the topological features of a protein directly from its primary amino acid sequence. The computer program generates values for surface accessibility parameters and combines these values with those obtained for regional backbone flexibility and predicted secondary structure. The output of this algorithm, the antigenic index, is used to create a linear surface contour profile of the protein. Because most, if not all, antigenic sites are located within surface exposed regions of a protein, the program offers a reliable means of predicting potential antigenic determinants. We have tested the ability of this program to generate accurate surface contour profiles and predict antigenic sites from the linear amino acid sequences of well-characterized proteins and found a strong correlation between the predictions of the antigenic index and known structural and biological data.

Item Type:Article
Additional Information:© 1988 Oxford University Press. Received on August 17, 1987: accepted on December 31, 1987.
Issue or Number:1
Record Number:CaltechAUTHORS:20120604-110115303
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31795
Deposited By: Tony Diaz
Deposited On:04 Jun 2012 23:13
Last Modified:03 Oct 2019 03:55

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