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Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis in major depression

Goldstein, M. R. and Plante, D. T. and Hulse, B. K. and Sarasso, S. and Landsness, E. C. and Tononi, G. and Benca, R. M. (2012) Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis in major depression. Acta Psychiatrica Scandinavica, 125 (6). pp. 468-477. ISSN 0001-690X. PMCID PMC3303968. https://resolver.caltech.edu/CaltechAUTHORS:20120604-143101245

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Abstract

Objective: Sleep homeostasis is altered in major depressive disorder (MDD). Pre- to postsleep decline in waking auditory evoked potential (AEP) amplitude has been correlated with sleep slow wave activity (SWA), suggesting that overnight changes in waking AEP amplitude are homeostatically regulated in healthy individuals. This study investigated whether the overnight change in waking AEP amplitude and its relation to SWA is altered in MDD. Method: Using 256-channel high-density electroencephalography, all-night sleep polysomnography and single-tone waking AEPs pre- and postsleep were collected in 15 healthy controls (HC) and 15 non-medicated individuals with MDD. Results: N1 and P2 amplitudes of the waking AEP declined after sleep in the HC group, but not in MDD. The reduction in N1 amplitude also correlated with fronto-central SWA in the HC group, but a comparable relationship was not found in MDD, despite equivalent SWA between groups. No pre- to postsleep differences were found for N1 or P2 latencies in either group. These findings were not confounded by varying levels of alertness or differences in sleep variables between groups. Conclusion: MDD involves altered sleep homeostasis as measured by the overnight change in waking AEP amplitude. Future research is required to determine the clinical implications of these findings.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/j.1600-0447.2011.01796.xDOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303968PubMed CentralArticle
ORCID:
AuthorORCID
Hulse, B. K.0000-0002-7117-7036
Additional Information:© 2012 John Wiley & Sons A/S. Issue published online: 10 May 2012; Article first published online: 19 November 2011; Accepted for publication October 13, 2011. This research was funded by the National Institute of Mental Health (5P20MH077967 to GT and RB, and F30MH082601 to EL). The authors would like to thank the polysomnographic technologists from Wisconsin Sleep for working with participants overnight and scoring the sleep recordings; Meredith Rumble, PhD, and Elizabeth Frei, PhD, for conducting the SCIDs; the undergraduate research assistants for their help collecting the data; Tim Wanger for his assistance in processing the hdEEG sleep data; Jennifer Noe and Kate Sprecher for their logistical contributions; and Brady Riedner, PhD, for his helpful feedback in conducting additional analyses and manuscript revisions.
Funders:
Funding AgencyGrant Number
NIH5P20MH077967
NIH PostdoctoralF30MH082601
Subject Keywords:major depressive disorder; auditory evoked potentials; sleep; homeostasis; slow-wave sleep
Issue or Number:6
PubMed Central ID:PMC3303968
Record Number:CaltechAUTHORS:20120604-143101245
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120604-143101245
Official Citation:Goldstein, M. R., Plante, D. T., Hulse, B. K., Sarasso, S., Landsness, E. C., Tononi, G. and Benca, R. M. (2012), Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis in major depression. Acta Psychiatrica Scandinavica, 125: 468–477. doi: 10.1111/j.1600-0447.2011.01796.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31803
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:04 Jun 2012 22:02
Last Modified:31 Oct 2019 21:35

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