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Small RNA in the nucleus: the RNA-chromatin ping-pong

Olovnikov, Ivan and Aravin, Alexei A. and Fejes Toth, Katalin (2012) Small RNA in the nucleus: the RNA-chromatin ping-pong. Current Opinion in Genetics and Development, 22 (2). pp. 164-171. ISSN 1879-0380. PMCID PMC3345048.

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Eukaryotes use several classes of small RNA molecules to guide diverse protein machineries to target messenger RNA. The role of small RNA in post-transcriptional regulation of mRNA stability and translation is now well established. Small RNAs can also guide sequence-specific modification of chromatin structure and thus contribute to establishment and maintenance of distinct chromatin domains. In this review we summarize the model for the inter-dependent interaction between small RNA and chromatin that has emerged from studies on fission yeast and plants. We focus on recent results that link a distinct class of small RNAs, the piRNAs, to chromatin regulation in animals.

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Additional Information:© 2012 Elsevier. Available online 19 February 2012. We thank members of the Aravin Lab for helpful discussion and comments on the manuscript. This work is supported by grants from the National Institutes of Health (DP2 OD007371A, R00 HD057233 and R01GM097363) to A.A.A. and by the Ellison Medical Foundation grant to K.F.T.
Funding AgencyGrant Number
NIHDP2 OD007371A
NIHR00 HD057233
NIHR01 GM097363
Ellison Medical FoundationUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC3345048
Record Number:CaltechAUTHORS:20120620-092051198
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Official Citation:Ivan Olovnikov, Alexei A Aravin, Katalin Fejes Toth, Small RNA in the nucleus: the RNA-chromatin ping-pong, Current Opinion in Genetics & Development, Volume 22, Issue 2, April 2012, Pages 164-171, ISSN 0959-437X, 10.1016/j.gde.2012.01.002. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31973
Deposited By: Ruth Sustaita
Deposited On:20 Jun 2012 16:38
Last Modified:03 Oct 2019 03:56

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