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Molecular Insights into Parkinson’s Disease

Rochet, Jean-Christophe and Hay, Bruce A. and Guo, Ming (2012) Molecular Insights into Parkinson’s Disease. In: Molecular Biology of Neurodegenerative Diseases. Progress in Molecular Biology and Translational Science . No.107. Academic Press , Amsterdam, pp. 125-188. ISBN 9780123858832.

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Mutations in SNCA, PINK1, parkin, and DJ-1 are associated with autosomal-dominant or autosomal-recessive forms of Parkinson's disease (PD), the second most common neurodegenerative disorder. Studies on the structural and functional properties of the corresponding gene products have provided significant insights into the molecular underpinnings of familial PD and the much more common sporadic forms of the disease. Here, we review recent advances in our understanding of four PD-related gene products: α-synuclein, parkin, PINK1, and DJ-1. In Part 1, we review new insights into the role of α-synuclein in PD. In Part 2, we summarize the latest developments in understanding the role of mitochondrial dysfunction in PD, emphasizing the role of the PINK1/parkin pathway in regulating mitochondrial dynamics and mitophagy. The role of DJ-1 is also discussed. In Part 3, we point out converging pathways and future directions.

Item Type:Book Section
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Additional Information:© 2012 Elsevier. We apologize to those whose work has not been cited because of space constraints. This work is supported by grants and funds from the National Institutes of Health (R03, R21, R01) and the Michael J. Fox Foundation to J.-C.R., and from the National Institutes of Health (R01, K02), the Glenn Family Foundation, the Esther A. and Joseph Klingenstein Fellowship, and the McKnight Foundation of Neuroscience to M.G.
Funding AgencyGrant Number
Michael J. Fox FoundationUNSPECIFIED
Glenn Family FoundationUNSPECIFIED
Esther A. and Joseph Klingestein FellowshipUNSPECIFIED
McKnight Foundation of NeuroscienceUNSPECIFIED
Subject Keywords:α-Synuclein; PINK1; Parkin; DJ-1; Mitochondria
Series Name:Progress in Molecular Biology and Translational Science
Issue or Number:107
Record Number:CaltechAUTHORS:20120620-143827080
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Official Citation:Jean-Christophe Rochet, Bruce A. Hay, Ming Guo, chapter 5 - Molecular Insights into Parkinson's Disease, In: David B. Teplow, Editor(s), Progress in Molecular Biology and Translational Science, Academic Press, 2012, Volume 107, Pages 125-188, ISSN 1877-1173, ISBN 9780123858832, 10.1016/B978-0-12-385883-2.00011-4. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:31993
Deposited By: Ruth Sustaita
Deposited On:21 Jun 2012 15:14
Last Modified:09 Nov 2021 20:02

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