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The Catalytic Redox Activity of Prion Protein–Cu^(II) is Controlled by Metal Exchange with the Zn^(II)–Thiolate Clusters of Zn_7Metallothionein-3

Meloni, Gabriele and Crameri, Andrea and Fritz, Günter and Davies, Paul and Brown, David R. and Kroneck, Peter M. H. and Vašák, Milan (2012) The Catalytic Redox Activity of Prion Protein–Cu^(II) is Controlled by Metal Exchange with the Zn^(II)–Thiolate Clusters of Zn_7Metallothionein-3. ChemBioChem, 13 (9). pp. 1261-1265. ISSN 1439-4227. https://resolver.caltech.edu/CaltechAUTHORS:20120621-143910899

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Abstract

Silencing prion: Copper-catalyzed transformations of prion protein (PrP) lead to the production of reactive oxygen species (ROS), PrP oxidation, and cleavage and aggregation in transmissible spongiphorm encephalopathies. Zn_7MT-3 efficiently targets Cu^(II) bound in different coordination modes to PrP–Cu^(II). By an unusual redox-dependent metal-swap reaction, MT-3 modulates the catalytic redox properties of PrP–Cu^(II).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/cbic.201200198 DOIUNSPECIFIED
http://onlinelibrary.wiley.com/doi/10.1002/cbic.201200198/abstractPublisherUNSPECIFIED
Additional Information:© 2012 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim. Received: March 21, 2012. Published online on May 21, 2012. We thank Dr. Serge, Chesnov (Functional Genomics Center Zürich, Switzerland) for recording the ESI-MS spectra. The work was supported by the Forschungskredit der Universität Zürich (Switzerland) Grant 54043901 (G.M.) and Swiss National Science Foundation Grant 31003A-1118884 (M.V.).
Funders:
Funding AgencyGrant Number
Forschungskredit der Universität Zürich54043901
Swiss National Science Foundation (SNSF)31003A-1118884
Subject Keywords:copper; metallothionein-3; prion proteins; reactive oxygen species; zinc
Issue or Number:9
Record Number:CaltechAUTHORS:20120621-143910899
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120621-143910899
Official Citation:Meloni, G., Crameri, A., Fritz, G., Davies, P., Brown, D. R., Kroneck, P. M. H. and Vašák, M. (2012), The Catalytic Redox Activity of Prion Protein–CuII is Controlled by Metal Exchange with the ZnII–Thiolate Clusters of Zn7Metallothionein-3. ChemBioChem, 13: 1261–1265. doi: 10.1002/cbic.201200198
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32017
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Jun 2012 22:28
Last Modified:03 Oct 2019 03:57

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