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New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

Stroncek, David F. and Berger, Carolina and Cheever, Martin A. and Childs, Richard W. and Dudley, Mark E. and Flynn, Peter and Gattinoni, Luca and Heath, James R. and Kalos, Michael and Marincola, Francesco M. and Miller, Jeffrey S. and Mostoslavsky, Gustavo and Powell, Daniel J., Jr. and Rao, Mahendra and Restifo, Nicholas P. and Rosenberg, Steven A. and O'Shea, John and Melief, Cornelis J. M. (2012) New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer. Journal of Translational Medicine, 10 . Art. No. 48. ISSN 1479-5876. PMCID PMC3362772. https://resolver.caltech.edu/CaltechAUTHORS:20120622-114310759

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Abstract

A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly. Conventional cellular therapies, such as tumor infiltrating lymphocytes (TIL), are becoming more effective and more available. Gene therapy is becoming an important tool in adoptive cell therapy. Lymphocytes are being engineered to express high affinity T cell receptors (TCRs), chimeric antibody-T cell receptors (CARs) and cytokines. T cell subsets with more naïve and stem cell-like characteristics have been shown in pre-clinical models to be more effective than unselected populations and it is now possible to reprogram T cells and to produce T cells with stem cell characteristics. In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1186/1479-5876-10-48DOIArticle
http://www.translational-medicine.com/content/10/1/48PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362772/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:© 2012 Stroncek et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 21 February 2012 Accepted: 15 March 2012 Published: 15 March 2012.
PubMed Central ID:PMC3362772
Record Number:CaltechAUTHORS:20120622-114310759
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120622-114310759
Official Citation:Stroncek et al.: New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer. Journal of Translational Medicine 2012 10:48.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32044
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:22 Jun 2012 20:26
Last Modified:03 Oct 2019 03:57

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