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Monoclonal antibodies to the cells of a regenerating limb

Kintner, Chris R. and Brockes, Jeremy P. (1985) Monoclonal antibodies to the cells of a regenerating limb. Journal of Embryology and Experimental Morphology, 89 . pp. 37-55. ISSN 0022-0752.

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Monoclonal antibodies were raised against differentiated cells, and blastemal cells from regenerating limbs of adult newts (Notophthalmus viridescens) and screened for specific staining by immunocytochemistry. In addition to antibodies that identify muscle, Schwann cells and cartilage, two reagents were specific for subpopulations of blastemal cells. One of these latter antibodies, termed 22/18, has provided new evidence about the origin of blastemal cells from Schwann cells and rnyofibres, and also identifies blastemal cells whose division is persistently dependent on the nerve supply.

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Additional Information:© 1985 The Company of Biologists Limited. Accepted 26 April 1985. We would like to thank Sarah Joslin for excellent technical assistance and Drs Donna Fekete, Herman Gordon, Nigel Holder and Russel Fernald for critical reading of the manuscript. C.K. was supported by a NRSA fellowship from the National Institute of Health.
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Subject Keywords:monoclonal antibodies, regeneration, cell markers, Notophthalmus viridescens, blastema, Schwann cells.
Record Number:CaltechAUTHORS:20120629-090859602
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Official Citation: Chris R. Kintner and Jeremy P. Brockes Monoclonal antibodies to the cells of a regenerating limb J Embryol Exp Morphol October 1985 89:37-55
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32190
Deposited By: Ruth Sustaita
Deposited On:02 Jul 2012 16:10
Last Modified:03 Oct 2019 03:58

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