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The claustrum and insula in Microcebus murinus: a high resolution diffusion imaging study

Park, Soyoung and Tyszka, J. Michael and Allman, John M. (2012) The claustrum and insula in Microcebus murinus: a high resolution diffusion imaging study. Frontiers in Neuroanatomy, 6 . Art. No. 21. ISSN 1662-5129. PMCID PMC3374366. https://resolver.caltech.edu/CaltechAUTHORS:20120710-112107100

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Abstract

The claustrum and the insula are closely juxtaposed in the brain of the prosimian primate, the gray mouse lemur (Microcebus murinus). Whether the claustrum has closer affinities with the cortex or the striatum has been debated for many decades. Our observation of histological sections from primate brains and genomic data in the mouse suggest former. Given this, the present study compares the connections of the two structures in Microcebus using high angular resolution diffusion imaging (HARDI, with 72 directions), with a very small voxel size (90 micra), and probabilistic fiber tractography. High angular and spatial resolution diffusion imaging is non-destructive, requires no surgical interventions, and the connection of each and every voxel can be mapped, whereas in conventional tract tracer studies only a few specific injection sites can be assayed. Our data indicate that despite the high genetic and spatial affinities between the two structures, their connectivity patterns are very different. The claustrum connects with many cortical areas and the olfactory bulb; its strongest probabilistic connections are with the entorhinal cortex, suggesting that the claustrum may have a role in spatial memory and navigation. By contrast, the insula connects with many subcortical areas, including the brainstem and thalamic structures involved in taste and visceral feelings. Overall, the connections of the Microcebus claustrum and insula are similar to those of the rodents, cat, macaque, and human, validating our results. The insula in the Microcebus connects with the dorsolateral frontal cortex in contrast to the mouse insula, which has stronger connections with the ventromedial frontal lobe, yet this is consistent with the dorsolateral expansion of the frontal cortex in primates. In addition to revealing the connectivity patterns of the Microcebus brain, our study demonstrates that HARDI, at high resolutions, can be a valuable tool for mapping fiber pathways for multiple sites in fixed brains in rare and difficult-to-obtain species.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3389/fnana.2012.00021DOIArticle
http://www.frontiersin.org/Neuroanatomy/10.3389/fnana.2012.00021/abstractPublisherArticle
ORCID:
AuthorORCID
Tyszka, J. Michael0000-0001-9342-9014
Additional Information:© 2012 Park, Tyszka and Allman. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. Received: 27 February 2012; Accepted: 22 May 2012; Published online: 13 June 2012. We wish to thank Dr.Russell Jacobs of the Beckman Institute at California Institute of Technology for providing the Microcebus brains, and Dr. Jason Kaufman for processing some of the imaging data. This study was supported by the James S. McDonnell Foundation.
Funders:
Funding AgencyGrant Number
James S. McDonnell FoundationUNSPECIFIED
Subject Keywords:Microcebus murinus; gray mouse lemur; claustrum; insula; HARDI; probabilistic fiber tractography
PubMed Central ID:PMC3374366
Record Number:CaltechAUTHORS:20120710-112107100
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120710-112107100
Official Citation:Park S, Tyszka JM and Allman JM (2012) The claustrum and insula in Microcebus murinus: a high resolution diffusion imaging study. Front. Neuroanat. 6:21. doi: 10.3389/fnana.2012.00021
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32327
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:10 Jul 2012 18:39
Last Modified:03 Oct 2019 03:59

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