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Chromosomal location of structural genes encoding murine immunoglobulin λ light chains. Genetics of murine λ light chains

D'Eustachio, Peter and Bothwell, Alfred L. M. and Takaro, Timothy K. and Baltimore, David and Ruddle, Frank H. (1981) Chromosomal location of structural genes encoding murine immunoglobulin λ light chains. Genetics of murine λ light chains. Journal of Experimental Medicine, 153 (4). pp. 793-800. ISSN 0022-1007.

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To determine the chromosomal localization of murine lambda light (L) chain structural genes, DNA from a panel of 11 mouse x hamster somatic cell hybrids was scored for the presence of sequences homologous to cloned lambda DNA probe molecules. Six of the hybrids had detectable lambda I and lambda II gene sequences. In all six, the full complement of murine sequences was present, and in its germline configuration. The remaining hybrids lacked any detectable murine lambda L chain gene sequences. The only mouse chromosome present in all of the positive hybrids and absent from the negative ones was number 16, allowing the assignment of lambda L chain structural genes to this chromosome. Together with the previous assignments of the kappa L chain genes to chromosome 6 and heavy chain genes to chromosome 12, this finding completes the mapping of Ig structural genes in the mouse at the chromosomal level.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1981 Rockefeller University Press. Received for publication 16 September 1980. Supported by grants GM-09966 (to F.H.R.) and CA-14051 (to D.B.) from the National Institutes of Health, grant PCM-7912028 (to F.H.R.) from the National Science Foundation, and grant VC-41 (to D.B.) from the American Cancer Society. We thank Drs. D. Pravtcheva, M. L. Gefter, and G. Scangos for their help, suggestions, and gifts of material, and Ms. E. Nichols and Ms. S. Parka for their expert technical assistance.
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American Cancer SocietyVC-41
Record Number:CaltechAUTHORS:20120718-101950135
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32545
Deposited By: Jason Perez
Deposited On:18 Jul 2012 20:37
Last Modified:31 Oct 2017 18:02

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