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The Brain Activity Map Project and the Challenge of Functional Connectomics

Alivisatos, A. Paul and Chun, Miyoung and Church, George M. and Greenspan, Ralph J. and Roukes, Michael L. and Yuste, Rafael (2012) The Brain Activity Map Project and the Challenge of Functional Connectomics. Neuron, 74 (6). pp. 970-974. ISSN 0896-6273. PMCID PMC3597383. doi:10.1016/j.neuron.2012.06.006.

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The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain Activity Map Project, aimed at reconstructing the full record of neural activity across complete neural circuits. This technological challenge could prove to be an invaluable step toward understanding fundamental and pathological brain processes.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Alivisatos, A. Paul0000-0001-6895-9048
Greenspan, Ralph J.0000-0002-6787-2845
Roukes, Michael L.0000-0002-2916-6026
Additional Information:© 2012 Elsevier Inc. Available online 20 June 2012. This collaboration arose from a workshop held at Chicheley Hall, the Kavli Royal Society International Centre, supported by The Kavli Foundation, the Gatsby Charitable Foundation, and the Allen Institute for Brain Science. We also thank A.S. Chiang, K. Deisseroth, S. Fraser, C. Koch, E. Marder, O. Painter, H. Park, D. Peterka, S. Seung, A. Siapas, A. Tolias, and X. Zhuang— participants at a smaller, subsequent Kavli Futures Symposium, where initial ideas were jointly refined. We acknowledge support from the DOE (A.P.A.), NHGRI (G.M.C.), NIH and the Mathers Foundation (R.J.G.), NIH and Fondation pour la Recherche et l’Enseignement Superieur, Paris (M.L.R.), and the Keck Foundation and NEI (R.Y.). A more extensive version of this paper and additional documents about the BAM can be found at
Group:Kavli Nanoscience Institute
Funding AgencyGrant Number
Kavli FoundationUNSPECIFIED
Gatsby Charitable FoundationUNSPECIFIED
Allen Institute for Brain ScienceUNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
National Human Genome Research Institute (NHGRI)UNSPECIFIED
Mathers FoundationUNSPECIFIED
Fondation pour la Recherche et l’Enseignement SuperieurUNSPECIFIED
Keck FoundationUNSPECIFIED
National Eye InstituteUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC3597383
Record Number:CaltechAUTHORS:20120723-113633591
Persistent URL:
Official Citation:A. Paul Alivisatos, Miyoung Chun, George M. Church, Ralph J. Greenspan, Michael L. Roukes, Rafael Yuste, The Brain Activity Map Project and the Challenge of Functional Connectomics, Neuron, Volume 74, Issue 6, 21 June 2012, Pages 970-974, ISSN 0896-6273, 10.1016/j.neuron.2012.06.006. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32644
Deposited On:23 Jul 2012 21:32
Last Modified:09 Nov 2021 21:28

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