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Mouse Immunoglobulin Heavy Chains Are Coded by Multiple Germ Line Variable Region Genes

Barstad, P. and Farnsworth, V. and Weigert, M. and Cohn, M. and Hood, L. (1974) Mouse Immunoglobulin Heavy Chains Are Coded by Multiple Germ Line Variable Region Genes. Proceedings of the National Academy of Sciences of the United States of America, 71 (10). pp. 4096-4100. ISSN 0027-8424.

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The N-terminal 20 residues of 13 heavy immunoglobulin chains from myeloma protein of the BALB/c mouse are compared with the same residues of 15 other heavy chains described in the literature. Sixteen of 28 sequences are different from one another. These proteins fall into four major sets, with 18 of the proteins in the largest set being further divisible into at least five subsets. This pattern of diversity suggests there are at least eight germ line genes coding for the variable regions of mouse heavy chain. Many of the immunoglobulins from which these heavy chains are derived exhibit binding activity for various haptens. The differing hapten specificities are closely correlated with distinct primary amino-acid sequences.

Item Type:Article
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Hood, L.0000-0001-7158-3678
Additional Information:© 1974 National Academy of Sciences. Communicated by Ray D. Owen, June 20, 1974. This investigation was supported by NIH Grant AI 10781 and NSF Grant GB 27605 to L.H.; NIH A105875 and CA 05213 to M.C.; and NIH Grant GM 20964 to M.W. L.H. has an NIH Career Development Award. M.W. has an American Cancer Society Faculty Research Award no. PRA-59. We thank M. Potter for tumor MOPC 104E.
Funding AgencyGrant Number
NIHAI 10781
NSFGB 27605
NIHCA 05213
NIHGM 20964
NIH Career Development AwardUNSPECIFIED
American Cancer Society Faculty Research awardPRA-59
Subject Keywords:amino-acid sequence, sequenator, BALB, c mouse, hapten binding, selection
Issue or Number:10
Record Number:CaltechAUTHORS:20120725-093029888
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Official Citation: P. Barstad, V. Farnsworth, M. Weigert, M. Cohn, and L. Hood Mouse Immunoglobulin Heavy Chains Are Coded by Multiple Germ Line Variable Region Genes PNAS 1974 71 (10) 4096-4100
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32701
Deposited By: Ruth Sustaita
Deposited On:25 Jul 2012 16:49
Last Modified:03 Mar 2020 13:01

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