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Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis

Peters, Gordon and Harada, Fumio and Dahlberg, James E. and Panet, Amos and Haseltine, William A. and Baltimore, David (1977) Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis. Journal of Virology, 21 (3). pp. 1031-1041. ISSN 0022-538X.

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The small RNAs of Moloney murine leukemia virus (M-MuLV) were fractionated into at least 15 species by two-dimensional polyacrylamide gel electrophoresis. The pattern of small RNAs is significantly different from that of Rous sarcoma virus. A subset of the virion small RNAs is associated with the genome RNA in the 70S complex. One of the associated molecules, a cellular tRNA, is tightly bound to the genome RNA and serves as the major primer for M-MuLV RNA-directed DNA synthesis in vitro.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1977 American Society for Microbiology. Received for publication 22 October 1976. Supported by Public Health Service grants CA-15166 to J. E. Dahlberg and CA-14051, both from the National Cancer Institute, and a contract from Virus Cancer Program of National Cancer Institute to D. Baltimore. W. A. Haseltine was supported by the Helen Hay Whitney Foundation. D. Baltimore is a Research Professor of American Cancer Society.
Funding AgencyGrant Number
National Cancer Institute Public Health ServiceCA-15166
National Cancer Institute Public Health ServiceCA-14051
National Cancer Institute Virus Cancer ProgramUNSPECIFIED
Helen Hay Whitney FoundationUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20120801-114336136
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ID Code:32838
Deposited On:01 Aug 2012 20:15
Last Modified:03 Oct 2019 04:04

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