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Isolation and identification of the conidial germination factor of Neurospora crassa

Horowitz, N. H. and Charlang, Gisela and Horn, George and Williams, Norma P. (1976) Isolation and identification of the conidial germination factor of Neurospora crassa. Journal of Bacteriology, 127 (1). pp. 135-140. ISSN 0021-9193. PMCID PMC233043.

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The germination-essential substance (germination factor [GF]) that is lost from conidia of Neurospora crassa on exposure to solutions of low water activity has been isolated and identified as a group of iron-transport compounds, or siderochromes. The principal siderochrome of conidia is ferricrocin, a cyclic hexapeptide. A closely related substance, ferrichrome C, is tentatively identified as a minor constituent. The same substances are also present in extracts of mycelium along with small amounts of a third siderochrome, which has not been identified. The GF activity of culture filtrates is due to coprogen, the only siderochrome previously identified with N. crassa.

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Additional Information:© 1976 American Society for Microbiology. Received for publication 13 February 1976. We are indebted to the Merck, Sharp & Dohme Research Laboratories and T. H. Stoudt for the gift of GF-containing concentrates made from N. crassa. We thank G. Winkelmann for a sample of ferricrocin, W. Keller-Schierlein for samples of ferricrocin, ferrichrysin, and ferrichrome, and J. B. Neilands for samples of ferrichrome C, ferrichrome A, and rhodotorulic acid. We also acknowledge the invaluable help of Robert M. Horowitz, who performed and interpreted the NMR spectroscopy. This research was supported by a grant from the National Aeronautics and Space Administration (NGR 05-002-121).
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NASANGR 05-002-121
Issue or Number:1
PubMed Central ID:PMC233043
Record Number:CaltechAUTHORS:20120802-132802393
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ID Code:32889
Deposited On:02 Aug 2012 22:45
Last Modified:03 Oct 2019 04:04

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