Garbett, K. A. and Hsiao, E. Y. and Kálmán, S. and Patterson, P. H. and Mirnics, K. (2012) Effects of maternal immune activation on gene expression patterns in the fetal brain. Translational Psychiatry, 2 . Art. No. e98. ISSN 2158-3188. PMCID PMC3337077. doi:10.1038/tp.2012.24. https://resolver.caltech.edu/CaltechAUTHORS:20120803-134745067
![]()
|
PDF
- Published Version
Creative Commons Attribution Non-commercial No Derivatives. 513kB | |
![]() |
MS Excel
- Supplemental Material
Creative Commons Attribution Non-commercial No Derivatives. 19kB | |
![]() |
MS Excel
- Supplemental Material
Creative Commons Attribution Non-commercial No Derivatives. 256kB |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20120803-134745067
Abstract
We are exploring the mechanisms underlying how maternal infection increases the risk for schizophrenia and autism in the offspring. Several mouse models of maternal immune activation (MIA) were used to examine the immediate effects of MIA induced by influenza virus, poly(I:C) and interleukin IL-6 on the fetal brain transcriptome. Our results indicate that all three MIA treatments lead to strong and common gene expression changes in the embryonic brain. Most notably, there is an acute and transient upregulation of the α, β and γ crystallin gene family. Furthermore, levels of crystallin gene expression are correlated with the severity of MIA as assessed by placental weight. The overall gene expression changes suggest that the response to MIA is a neuroprotective attempt by the developing brain to counteract environmental stress, but at a cost of disrupting typical neuronal differentiation and axonal growth. We propose that this cascade of events might parallel the mechanisms by which environmental insults contribute to the risk of neurodevelopmental disorders such as schizophrenia and autism.
Item Type: | Article | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||||||
ORCID: |
| ||||||||||||||||
Additional Information: | © 2012 Macmillan Publishers Limited. Received 09 November 2011; revised 27 February 2012; accepted 03 March 2012. Published online 3 April 2012. We are thankful for the microarray work performed by the Genome Sciences Resource at Vanderbilt University and for valuable comments of the manuscript provided by Martin J Schmidt. The experiments were supported by NIH R01 MH067234 (KM), MH079299 (KM), Cure Autism Now (PHP), McKnight Foundation Neuroscience of Brain Disorder Award (PHP), NIH RO1 MH067978 (PHP), Autism Speaks Dennis Weatherstone Pre-Doctoral Fellowship (EYH) and NRSA 5 T32GM07737 (EYH). | ||||||||||||||||
Funders: |
| ||||||||||||||||
Subject Keywords: | autism; brain; crystallin; gene expression; maternal immune activation; schizophrenia | ||||||||||||||||
PubMed Central ID: | PMC3337077 | ||||||||||||||||
DOI: | 10.1038/tp.2012.24 | ||||||||||||||||
Record Number: | CaltechAUTHORS:20120803-134745067 | ||||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20120803-134745067 | ||||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||
ID Code: | 32920 | ||||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||||
Deposited By: | Tony Diaz | ||||||||||||||||
Deposited On: | 03 Aug 2012 22:38 | ||||||||||||||||
Last Modified: | 09 Nov 2021 21:31 |
Repository Staff Only: item control page