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Efficient and Highly Aldehyde Selective Wacker Oxidation

Teo, Peili and Wickens, Zachary K. and Dong, Guangbin and Grubbs, Robert H. (2012) Efficient and Highly Aldehyde Selective Wacker Oxidation. Organic Letters, 14 (13). pp. 3237-3239. ISSN 1523-7060. doi:10.1021/ol301240g. https://resolver.caltech.edu/CaltechAUTHORS:20120807-073334484

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Abstract

A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl_2(MeCN)_2, 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ol301240gDOIArticle
http://pubs.acs.org/doi/abs/10.1021/ol301240gPublisherArticle
ORCID:
AuthorORCID
Grubbs, Robert H.0000-0002-0057-7817
Additional Information:© 2012 American Chemical Society. Received May 17, 2012. Publication Date (Web): June 13, 2012. We gratefully acknowledge financial support from King Abdullah University of Science and Technology Centre in Development, King Fahd University of Petroleum and Minerals, and the NSF.G.D. thanks the Camille and Henry Dreyfus Foundation for a postdoctoral fellowship. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
King Abdullah University of Science and Technology (KAUST)UNSPECIFIED
King Fahd University of Petroleum and Minerals (KFUPM)UNSPECIFIED
NSFUNSPECIFIED
Camille and Henry Dreyfus FoundationUNSPECIFIED
Issue or Number:13
DOI:10.1021/ol301240g
Record Number:CaltechAUTHORS:20120807-073334484
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120807-073334484
Official Citation:Efficient and Highly Aldehyde Selective Wacker Oxidation Peili Teo, Zachary K. Wickens, Guangbin Dong, and Robert H. Grubbs Organic Letters 2012 14 (13), 3237-3239
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32960
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Aug 2012 14:49
Last Modified:09 Nov 2021 21:31

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