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Mutations of Drosophila melanogaster that affect muscles

Deak, I. I. (1977) Mutations of Drosophila melanogaster that affect muscles. Journal of Embryology and Experimental Morphology, 40 (1). pp. 35-63. ISSN 0022-0752.

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Eight X-chromosome mutations (falling into five complementation groups) that affect the development and morphology of the indirect flight muscles of Drosophila melanogaster were investigated using histological, behavioural and genetic techniques. All of these mutations result in flightlessness, in a marked reduction in the ability of the flies to jump, and in the wings being held in abnormal positions. Mutations in each of the complementation groups have different effects on the morphology of the muscles. Two (flapwing, vertical wing) result in absence of most of the indirect flight muscle fibres, a third (upheld) is required for the gross organization of muscle structure, another (heldup) is involved in the maintenance of muscle structure once formed, and the fifth seems to be necessary for the detailed architecture of the muscle fibre (indented thorax). The analysis of flies genetically mosaic with respect to each mutation by the technique of fate-mapping suggests that three (heldup, upheld and indented thorax) of the genes concerned have their primary site of action in the musculature itself, while the other two (flapwing and vertical wing) may function primarily in the fat-body and tracheae respectively.

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Additional Information:© 1977 Company of Biologists Limited. Received 22 September, 1976, revised 20 December 1976. This work was done while I. I. Deak was the recipient of a fellowship from the Muscular Dystrophy Association, and was supported by a National Science Foundation grant to Dr Seymour Benzer. I thank Dr Benzer for his advice and support during my stay at the California Institute of Technology, Barbara Butler, Joyce Gorn and Mike Cousineau for their excellent assistance, Duncan Byers for his invaluable help with the computer programmes, and my many colleagues for their help and criticism throughout the work and throughout the preparation of this manuscript.
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Muscular Dystrophy AssociationUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20120807-140048129
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Official Citation:Mutations of Drosophila melanogaster that affect muscles. Deak II. J Embryol Exp Morphol. 1977 Aug;40:35-63.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:32988
Deposited By: Ruth Sustaita
Deposited On:07 Aug 2012 21:52
Last Modified:03 Oct 2019 04:05

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