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Flagellar Assembly Mutants in Escherichia coli

Silverman, Michael R. and Simon, Melvin I. (1972) Flagellar Assembly Mutants in Escherichia coli. Journal of Bacteriology, 112 (2). pp. 986-993. ISSN 0021-9193. PMCID PMC251511.

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Genetic and biochemical analysis of mutants defective in the synthesis of flagella in Escherichia coli revealed an unusual class of mutants. These mutants were found to produce short, curly, flagella-like filaments with low amplitude (∼0.06 μm). The filaments were connected to characteristic flagellar basal caps and extended for 1 to 2 μm from the bacterial surface. The mutations in these strains were all members of one complementation group, group E, which is located between his and uvrC. The structural, serological, and chemical properties of the filament derived from the mutants closely resemble those of the flagellar hook structure. On the basis of these properties, it is suggested that these filaments are “polyhooks”, i.e., repeated end-to-end polymers of the hook portion of the flagellum. Polyhooks are presumed to be the result of a defective cistron which normally functions to control the length of the hook region of the flagellum.

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Additional Information:© 1972 American Society for Microbiology. Received for publication 31 July 1972. A preliminary report of these findings was presented at the Annual Meeting of the American Society for Microbiology, 21 April 1972. We wish to thank Marcia Hilmen and Michael Kaiser for their excellent assistance and advice during this work. This investigation was supported by the National Science Foundation research grant GB-15655. M.R.S. was supported on the Public Health Service genetic training grant GM-00702 from the National Institute of General Medical Sciences.
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National Institute of General Medical Sciences Public Health ServiceGM-00702
Issue or Number:2
PubMed Central ID:PMC251511
Record Number:CaltechAUTHORS:20120809-140144104
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33060
Deposited By: Tony Diaz
Deposited On:09 Aug 2012 21:31
Last Modified:03 Oct 2019 04:06

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