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Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound

Yazdanfar, Siavash and Yang, Changhuei and Sarunic, Marinko V. and Izatt, Joseph A. (2005) Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound. Optics Express, 13 (2). pp. 410-416. ISSN 1094-4087.

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Doppler optical coherence tomography (DOCT) is a technique for simultaneous cross-sectional imaging of tissue structure and blood flow. We derive the fundamental uncertainty limits on frequency estimation precision in DOCT using the Cramer-Rao lower bound in the case of additive (e.g., thermal, shot) noise. Experimental results from a mirror and a scattering phantom are used to verify the theoretical limits. Our results demonstrate that the stochastic nature of frequency noise influences the precision of flow imaging, and that the noise model must be selected judiciously in order to estimate the frequency precision.

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Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2005 Optical Society of America Received 3 December 2004; revised 29 December 2004; accepted 5 January 2005 This study was supported by National Institutes of Health grant EY-13015. We gratefully acknowledge fruitful discussions with Jeff Krolik at Duke University, Bill Walker at the University of Virginia, and Jason Connor at Carnegie Mellon University. S. Yazdanfar is currently with the Massachusetts Institute of Technology, Cambridge, MA. C. Yang is currently with the California Institute of Technology, Pasadena, CA.
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Subject Keywords:Phase measurement; Laser Doppler velocimetry; Optical coherence tomography
Issue or Number:2
Record Number:CaltechAUTHORS:YAZoe05
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3313
Deposited By: Archive Administrator
Deposited On:30 May 2006
Last Modified:09 Mar 2020 13:19

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