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Morphogenesis of bacteriophage T4 in extracts of mutant-infected cells

Edgar, R. S. and Wood, W. B. (1966) Morphogenesis of bacteriophage T4 in extracts of mutant-infected cells. Proceedings of the National Academy of Sciences of the United States of America, 55 (3). pp. 498-505. ISSN 0027-8424. PMCID PMC224177.

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The complex structure of bacteriophage T4 includes a variety of proteins which become assembled into mature particles during intracellular development of the virus. Some insight into the genetic control of this process has been provided by physiological studies with conditional lethal mutants, which show that over 40 phage genes are involved in T4 morphogenesis (Fig. 1). However, the mechanisms by which components are assembled have remained obscure, due in part to the lack of a suitable system for their study. In the experiments reported below, conditional lethal mutants of strain T4D have been exploited to develop an in vitro system in which several of the steps in phage morphogenesis can be demonstrated.

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Additional Information:© 1963 National Academy of Sciences. Communicated by Max Delbraick, January 27, 1966. We wish to thank Mrs. Ilga Lielausis for excellent technical assistance and Dr. M. Moody for the preparation of electron micrographs. This research was supported by grants from the National Science Foundation (GB3930) and the U. S. Public Health Service (GM6965).
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U.S. Public Health ServiceGM06965
Issue or Number:3
PubMed Central ID:PMC224177
Record Number:CaltechAUTHORS:20120815-132812235
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Official Citation:R S Edgar and W B Wood Morphogenesis of bacteriophage T4 in extracts of mutant-infected cells PNAS 1966 55 (3) 498-505
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33221
Deposited On:16 Aug 2012 14:13
Last Modified:03 Oct 2019 04:08

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