Yang, Changhuei and Choma, Michael A. and Lamb, Laura E. and Simon, John D. and Izatt, Joseph A. (2004) Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. Optics Letters, 29 (12). pp. 1396-1398. ISSN 0146-9592. https://resolver.caltech.edu/CaltechAUTHORS:YANol04b
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Abstract
We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT). Our MCOCT scheme builds up a difference image revealing the distribution of phyA within a target sample from pairs of consecutive OCT A-scans acquired at a probe wavelength of 750 nm, both with and without additional illumination of the target sample with 660-nm light. We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 µM of phyA.
Item Type: | Article | ||||||||||||
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Additional Information: | © 2004 Optical Society of America. Received January 2, 2004. This research was supported by National Institutes of Health grant EB000243. | ||||||||||||
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Subject Keywords: | Optical coherence tomography; Medical and biological imaging; Molecular spectroscopy; Photochemistry | ||||||||||||
Issue or Number: | 12 | ||||||||||||
Record Number: | CaltechAUTHORS:YANol04b | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:YANol04b | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 3323 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Archive Administrator | ||||||||||||
Deposited On: | 30 May 2006 | ||||||||||||
Last Modified: | 09 Mar 2020 13:19 |
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