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Neurospora Mutant Exhibiting Hyperproduction of Amylase and Invertase

Gratzner, Howard and Sheehan, D. N. (1969) Neurospora Mutant Exhibiting Hyperproduction of Amylase and Invertase. Journal of Bacteriology, 97 (2). pp. 544-549. ISSN 0021-9193. PMCID PMC249725.

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A mutant strain of Neurospora crassa has been isolated which is derepressed for amylase and β-fructofuranosidase (invertase). Large amounts of the two enzymes were secreted into the culture medium upon depletion of exogenous carbon source. The resulting increases of the two extracellular enzymes were prevented by actinomycin D, cycloheximide, and glycerol. The starving cells of the mutant strain produced amylase and invertase de novo, as evidenced by incorporation of radioactive amino acids into the enzymes. Preliminary genetic studies indicate that these elevated enzyme levels described are due to a single gene mutation.

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Additional Information:© 1969 American Society for Microbiology. Received for publication 1 November 1968. This investigation was supported by National Science Foundation grant GB-4537 and by a special Public Health Service fellowship, IF3-CA-25,17301. We are grateful for the very able assistance of Stephen Bloom.
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Issue or Number:2
PubMed Central ID:PMC249725
Record Number:CaltechAUTHORS:20120816-093814786
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33256
Deposited On:16 Aug 2012 17:39
Last Modified:03 Oct 2019 04:08

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