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Steps in the neoplastic transformation of hamster embryo cells by polyoma virus

Vogt, Marguerite and Dulbecco, Renato (1963) Steps in the neoplastic transformation of hamster embryo cells by polyoma virus. Proceedings of the National Academy of Sciences of the United States of America, 49 (2). pp. 171-179. ISSN 0027-8424. PMCID PMC299772. https://resolver.caltech.edu/CaltechAUTHORS:20120816-144239596

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Abstract

Cultures of hamster embryo cells infected with polyoma virus undergo a characteristic transformation within several weeks after infection. The transformed cultures are constituted by highly atypical cells which have an abnormal morphology, grow rapidly in vitro, and give rise to progressively growing tumors when inoculated subcutaneously into the adult hamster. In the previous experiments, the transformed cells arose in mass cultures and their properties were only studied many cell generations after the original viruscell interaction had taken place. The experiments to be reported in this communication were undertaken to get some information on the properties of transformed cells at earlier stages after infection with polyoma virus. The experiments show that the atypical cells are produced in two main steps; moreover, they reveal some new characteristics of the transformed cells which may contribute to a clarification of the mechanism of transformation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.49.2.171DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299772/PubMed CentralArticle
Additional Information:© 1963 National Academy of Sciences. Communicated December 10, 1962. This work was aided by grants from the American Cancer Society, Inc., the National Foundation, and the U.S. Public Health Service, Grant No. E5131.
Funders:
Funding AgencyGrant Number
American Cancer SocietyUNSPECIFIED
National Foundation for Infantile ParalysisUNSPECIFIED
NIHE5131
Issue or Number:2
PubMed Central ID:PMC299772
Record Number:CaltechAUTHORS:20120816-144239596
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120816-144239596
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33277
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:16 Aug 2012 23:13
Last Modified:03 Oct 2019 04:08

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