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Interferometric phase-dispersion microscopy

Yang, Changhuei and Wax, Adam and Georgakoudi, Irene and Hanlon, Eugene B. and Badizadegan, Kamran and Dasari, Ramachandra R. and Feld, Michael S. (2000) Interferometric phase-dispersion microscopy. Optics Letters, 25 (20). pp. 1526-1528. ISSN 0146-9592.

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We describe a new scanning microscopy technique, phase-dispersion microscopy (PDM). The technique is based on measuring the phase difference between the fundamental and the second-harmonic light in a novel interferometer. PDM is highly sensitive to subtle refractive-index differences that are due to dispersion (differential optical path sensitivity, 5 nm). We apply PDM to measure minute amounts of DNA in solution and to study biological tissue sections. We demonstrate that PDM performs better than conventional phase-contrast microscopy in imaging dispersive and weakly scattering samples.

Item Type:Article
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Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2000 Optical Society of America Received July 20, 2000 This work was carried out at the Laser Biomedical Research Center of the Massachusetts Institute of Technology and was by supported by National Institutes of Health (NIH) grant P41-RR02594, National Science Foundation grant 9708265-CHE, and a grant from Hamamatsu Corporation. Adam Wax and Irene Georgakoudi were supported by NIH National Research Service Awards 1 F32 RR05075-01 and 1 F32 CA80345-01, respectively.
Funding AgencyGrant Number
Hamamatsu CorporationUNSPECIFIED
NIH Postdoctoral Fellowship1 F32 RR05075-01
NIH Postdoctoral Fellowship1 F32 CA80345-01
Subject Keywords:Heterodyne detectors; Microscopy; Optical coherence tomography; Phase measurement; Medical and biological imaging
Issue or Number:20
Record Number:CaltechAUTHORS:YANol00
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3328
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Deposited On:30 May 2006
Last Modified:09 Mar 2020 13:19

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