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ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos

Fishwick, K. J. and Kim, E. and Bronner, M. E. (2012) ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos. Developmental Dynamics, 241 (8). pp. 1325-1332. ISSN 1058-8388. PMCID PMC3399927. https://resolver.caltech.edu/CaltechAUTHORS:20120817-095005460

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Abstract

Background: The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families. Results: Here we identify a novel chick gene with close homology to double-stranded RNA-binding protein Interleukin enhancer binding factor 3 (ILF-3) in other species. Our results show that chick Ilf-3 is required for proper expression of the transcription factor, Zic-1, at the neural plate border. Conclusion: We have identified a novel chick gene and show it has a role in the correct specification of Zic-1 at the neural plate border.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/dvdy.23809DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.23809/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399927/PubMed CentralArticle
ORCID:
AuthorORCID
Bronner, M. E.0000-0003-4274-1862
Additional Information:© 2012 Wiley Periodicals, Inc. Issue published online: 17 Jul. 2012; Article first published online: 15 Jun. 2012; Accepted manuscript online: 25 May 2012 10:31AM EST; Manuscript Accepted: 20 May 2012. Original cDNA from library was cloned into pMES expression vector and the probe synthesized by S. McKeown. This work was funded by NIH grant HG004071 to Marianne E. Bronner.
Funders:
Funding AgencyGrant Number
NIHHG004071
Subject Keywords:neural crest; embryo; ILF-3; NF-90; neural plate border
Issue or Number:8
PubMed Central ID:PMC3399927
Record Number:CaltechAUTHORS:20120817-095005460
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120817-095005460
Official Citation:Fishwick, K. J., Kim, E. and Bronner, M. E. (2012), ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos. Dev. Dyn., 241: 1325–1332. doi: 10.1002/dvdy.23809
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33283
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:17 Aug 2012 20:53
Last Modified:03 Oct 2019 04:08

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