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Polarization-resolved second-harmonic-generation optical coherence tomography in collagen

Applegate, Brian E. and Yang, Changhuei and Rollins, Andrew M. and Izatt, Joseph A. (2004) Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. Optics Letters, 29 (19). pp. 2252-2254. ISSN 0146-9592.

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We describe a novel imaging technique, second-harmonic-generation optical coherence tomography (SHOCT). This technique combines the spatial resolution and depth penetration of optical coherence tomography (OCT) with the molecular sensitivity of second-harmonic-generation spectroscopy. As a consequence of the coherent detection required for OCT, polarization-resolved images arise naturally. We demonstrate this new technique on a skin sample from the belly of Icelandic salmon, acquiring polarization-resolved SHOCT and OCT images simultaneously.

Item Type:Article
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Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2004 Optical Society of America Received April 27, 2004 We acknowledge funding of this work through grant R24 EB000243 from the National Institutes of Health. B. E. Applegate acknowledges fellowship support through the National Institutes of Health (T32 EB001630).
Funding AgencyGrant Number
NIH Predoctoral FellowshipT32 EB001630
Subject Keywords:Optical coherence tomography; Multiharmonic generation; Optical nonlinearities in organic materials
Issue or Number:19
Record Number:CaltechAUTHORS:APPol04
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3333
Deposited By: Archive Administrator
Deposited On:31 May 2006
Last Modified:09 Mar 2020 13:19

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