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Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometry

Wax, Adam and Yang, Changhuei and Backman, Vadim and Kalashnikov, Maxim and Dasari, Ramachandra R. and Feld, Michael S. (2002) Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometry. Journal of the Optical Society of America A, 19 (4). pp. 737-744. ISSN 1084-7529.

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We employ a novel interferometer to measure the angular distribution of light backscattered by a turbid medium. Through comparison of the measured data with the predictions of Mie theory, we are able to determine the size of the scatterers comprising the medium with subwavelength precision. As the technique is based on low-coherence interferometry, we are able to examine the evolution of the angular distribution of scattered light as it propagates into the medium. The effects of multiple scattering as a function of penetration depth in the medium are analyzed. We also present various considerations for extending this technique to determining structural information in biological tissues, such as the effects of a distribution of particle sizes and the need to average out speckle contributions.

Item Type:Article
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URLURL TypeDescription
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2002 Optical Society of America Received May 25, 2001; revised manuscript received August 2, 2001; accepted September 26, 2001 This work was conducted at the MIT Laser Biomedical Research Center and was supported by grants from the Hamamatsu Corporation, the National Science Foundation (CHE-0111370), and the National Institutes of Health (NIH) through the National Center for Research Resources (P41-RR02594). Adam Wax is supported by National Research Service Award fellowship grant from the NIH (F32 RR05075).
Funding AgencyGrant Number
Hamamatsu CorporationUNSPECIFIED
NIH Postdoctoral FellowshipF32 RR05075
Subject Keywords:Optical coherence tomography; Inverse scattering
Issue or Number:4
Record Number:CaltechAUTHORS:WAXjosaa02
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3340
Deposited By: Archive Administrator
Deposited On:31 May 2006
Last Modified:09 Mar 2020 13:19

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