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Biodegradable polymer scaffolds for stem-cell based treatment of age-related macular degeneration

Piunova, Victoria and Patel, Paresma and Lee, Chonwoo and Tsie, Marlene and Grubbs, Robert H. and Clegg, Dennis O. (2012) Biodegradable polymer scaffolds for stem-cell based treatment of age-related macular degeneration. In: 244th ACS National Meeting & Exposition, August 19-23, 2012, Philadelphia, PA.

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This presentation will describe the formulation and biocompatibility testing of biodegradable polymer substrates for the treatment of age-related macular degeneration. As potential candidates two systems have been exploited: blends of poly-lactic-co-glycolic acid (PLGA)/poly-ε-caprolactone (PCL) of various compns. and a random terpolymer of poly-lactide-co-glicolide-co-caprolactone (PLGC). The choice of potential substrates was governed by several criteria, excellent biocompatibility, controlled biodegradability and the presence of functionality, suitable for further modification. Scaffolds were formulated by prepg. thin films of PLGA/PCL or PLGC followed by surface modification with a cyclic RGD peptide. To det. if the substrates can be applied as scaffolds for tissue engineering, their biocompatibility was examd. using in vitro expts.

Item Type:Conference or Workshop Item (Paper)
Grubbs, Robert H.0000-0002-0057-7817
Record Number:CaltechAUTHORS:20120822-074852754
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33432
Deposited By: Tony Diaz
Deposited On:27 Aug 2012 23:10
Last Modified:03 Oct 2019 04:09

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