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Higher order assemblies in the GET membrane protein-targeting pathway

Clemons, Bil and Chartron, Justin and Suloway, Christian (2012) Higher order assemblies in the GET membrane protein-targeting pathway. Protein Science, 21 (S1). p. 65. ISSN 0961-8368. https://resolver.caltech.edu/CaltechAUTHORS:20120827-142449938

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Abstract

Tail-anchor (TA) proteins represent an important and diverse class of membrane proteins that are unable to be targeted via the co-translational SRP pathway. Instead, recent discoveries have identified factors directly involved in targeting these proteins to the ER. In yeast, these proteins form the GET pathway. Our lab has focused on structural and mechanistic studies of these proteins. The pathway as we posit begins with cytoplasmic chaperones that deliver the TA-proteins to Sgt2, which routes the proteins to Get3 via a Get4/Get5 hetero-tetramer. Get3 then forms a stable complex with the TA and delivers the proteins to the ER membrane. We have begun characterizing these complexes using structural biology and biochemistry. I will frame a discussion of the pathway from our unique structural perspective presenting new results on parts of the pathway.


Item Type:Article
ORCID:
AuthorORCID
Clemons, Bil0000-0002-0021-889X
Issue or Number:S1
Record Number:CaltechAUTHORS:20120827-142449938
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120827-142449938
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33573
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Aug 2012 22:27
Last Modified:03 Oct 2019 04:11

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