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Chip-scale microscopy imaging

Zheng, Guoan (2012) Chip-scale microscopy imaging. Journal of Biophotonics, 5 (8-9). pp. 639-649. ISSN 1864-063X. doi:10.1002/jbio.201200043.

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Chip-scale microscopy imaging platforms are pivotal for improving the efficiency of modern biomedical and bioscience experiments. Their integration with other lab-on-a-chip techniques would allow rapid, reliable and high-throughput sample analysis for applications in diverse disciplines. In typical chip-scale microscopy imaging platforms, the light path can be generalized to the following steps: photons leave the light source, interact with the sample and finally are detected by the sensor. Based on the light path of these platforms, the current review aims to provide some insights on design strategies for chip-scale microscopy. Specifically, we analyze current chip-scale microscopy approaches from three aspects: illumination design, sample manipulation and substrate/imager modification. We also discuss some opportunities for future developments of chip-scale microscopy, such as time multiplexed structured illumination and hydrodynamic focusing for high throughput sample manipulation.

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Additional Information:© 2012 Wiley-VCH Verlag. Received 13 March 2012, revised 21 April 2012, accepted 25 April 2012. Published online 17 May 2012. The author gratefully acknowledges useful discussions and comments from Ying Min Wang and Jian Ren.
Subject Keywords: lensless imaging; digital in-line holography; contact imaging; optofluidic microscopy; ePetri dish; pre-detection light field manipulation
Issue or Number:8-9
Record Number:CaltechAUTHORS:20120905-075235125
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Official Citation:Zheng, G. (2012), Chip-scale microscopy imaging. J. Biophoton., 5: 639–649. doi: 10.1002/jbio.201200043
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33842
Deposited By: Ruth Sustaita
Deposited On:05 Sep 2012 20:41
Last Modified:09 Nov 2021 23:04

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