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Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

Chan, David C. (2012) Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health. Annual Review of Genetics, 46 . pp. 265-287. ISSN 0066-4197. doi:10.1146/annurev-genet-110410-132529.

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Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological function. Some of the major molecules mediating mitochondrial fusion and fission in mammals have been discovered, but the underlying molecular mechanisms are only partially unraveled. In particular, the cast of characters involved in mitochondrial fission needs to be clarified. By enabling content mixing between mitochondria, fusion and fission serve to maintain a homogeneous and healthy mitochondrial population. Mitochondrial dynamics has been linked to multiple mitochondrial functions, including mitochondrial DNA stability, respiratory capacity, apoptosis, response to cellular stress, and mitophagy. Because of these important functions, mitochondrial fusion and fission are essential in mammals, and even mild defects in mitochondrial dynamics are associated with disease. A better understanding of these processes likely will ultimately lead to improvements in human health.

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Chan, David C.0000-0002-0191-2154
Additional Information:© 2012 Annual Reviews. Review in Advance first posted online on August 29, 2012. I am grateful to Hsiuchen Chen for insightful comments on the manuscript. Work in my lab is supported by the Howard Hughes Medical Institute and the National Institutes of Health (GM062967 and GM083121).
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Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Record Number:CaltechAUTHORS:20120907-130054764
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33935
Deposited By: Tony Diaz
Deposited On:07 Sep 2012 20:43
Last Modified:09 Nov 2021 23:05

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