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A tissue-engineered jellyfish with biomimetic propulsion

Nawroth, Janna C. and Lee, Hyungsuk and Feinberg, Adam W. and Ripplinger, Crystal M. and McCain, Megan L. and Grosberg, Anna and Dabiri, John O. and Parker, Kevin Kit (2012) A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology, 30 (8). pp. 792-797. ISSN 1087-0156. PMCID PMC4026938. http://resolver.caltech.edu/CaltechAUTHORS:20120913-083123453

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Abstract

Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology and traditional soft robotics, and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept. The constructs, termed 'medusoids', were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding performance by quantitatively mimicking structural design, stroke kinematics and animal-fluid interactions. The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nbt.2269 DOIArticle
http://www.nature.com/nbt/journal/v30/n8/full/nbt.2269.htmlPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026938/PubMed CentralArticle
http://rdcu.be/csfdPublisherFree ReadCube access
ORCID:
AuthorORCID
Dabiri, John O.0000-0002-6722-9008
Additional Information:© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. Received 7 December 2011; accepted 14 May 2012; published online 22 July 2012. We acknowledge financial support from the Wyss Institute for Biologically Inspired Engineering at Harvard, the Harvard Materials Research Science and Engineering Center under National Science Foundation award number DMR-0213805, US National Institutes of Health grant 1 R01 HL079126 (K.K.P.), and from the office of Naval Research and National Science Foundation Program in Fluid Dynamics (J.O.D.). We acknowledge the Harvard Center for Nanoscale Science for use of facilities and the New England Aquarium for supplying jellyfish. We thank J. Goss, P.W. Alford, K.R. Sutherland, K. Balachandran, C. Regan, P. Campbell, S. Spina and A. Agarwal for comments and technical support. Author Contributions: K.K.P., J.O.D. and J.C.N. conceived the project, designed the experiments and prepared the manuscript. J.O.D. and J.C.N. developed the fluid model. J.C.N. did the experiments and analyzed the data. H.L., A.W.F., C.M.R., M.L.M. and A.G. supervised experiments, analyzed data and gave conceptual advice. M.L.M. isolated rat cardiomyocytes for experiments.
Group:GALCIT
Funders:
Funding AgencyGrant Number
Harvard University Wyss Institute for Biologically Inspired EngineeringUNSPECIFIED
Harvard Materials Research Science and Engineering CenterUNSPECIFIED
NSFDMR-0213805
NIH1 R01 HL079126
Office of Naval Research (ONR)UNSPECIFIED
PubMed Central ID:PMC4026938
Record Number:CaltechAUTHORS:20120913-083123453
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120913-083123453
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34050
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Sep 2012 18:18
Last Modified:23 Apr 2019 18:32

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