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Effect of Inhibitors on D-Xylose Permeability in Rat Diaphragm Muscle

Polleri, A. and Menozzi, P. and Norman, D. and Hechter, O. (1961) Effect of Inhibitors on D-Xylose Permeability in Rat Diaphragm Muscle. Journal of General Physiology, 44 (3). pp. 479-486. ISSN 0022-1295. PMCID PMC2195107. doi:10.1085/jgp.44.3.479.

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The influence of metabolic inhibitors and low temperatures upon D-xylose transfer has been studied in rat diaphragm muscle preparations in vitro. Using intact fiber preparations, it has been confirmed that at body temperature metabolic inhibitors like DNP have an insulin-like action in that they permit D-xylose to distribute into previously unavailable intracellular aqueous regions; inhibitors, unlike insulin, disturb cation distribution in association with increased sugar penetration. Although the studies with inhibitors suggest an energy requirement for maintenance of D-xylose exclusion, the D-xylose exclusion mechanism is effectively maintained at 0° for many hours, and under these conditions, inhibitors have little or no effect on D-xylose distribution, though they do produce potassium loss. In cut muscle fiber preparations, in which insulin significantly increases the rate at which D-xylose equilibrates between cell water and external medium, DNP does not increase the rate of D-xylose entry, but does abolish the effect of insulin in this preparation. The results suggest that insulin action upon sugar permeability in muscle involves two barrier systems; some of the characteristics of these systems have been defined.

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Additional Information:© 1961 Rockefeller University Press. Received for publication 17 June 1960. This work was aided by grants from the National Science Foundation and the Commonwealth Fund.
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Commonwealth FundUNSPECIFIED
Issue or Number:3
PubMed Central ID:PMC2195107
Record Number:CaltechAUTHORS:20120921-135555458
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Official Citation:Effect of Inhibitors on D-Xylose Permeability in Rat Diaphragm Muscle A. Polleri, P. Menozzi, D. Norman, and O. Hechter J Gen Physiol 1961 44:479-486. Published January 1, 1961, doi:10.1085/jgp.44.3.479
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34289
Deposited By: Ruth Sustaita
Deposited On:24 Sep 2012 22:01
Last Modified:09 Nov 2021 23:07

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