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Coding of the Reach Vector in Parietal Area 5d

Bremner, Lindsay R. and Andersen, Richard A. (2012) Coding of the Reach Vector in Parietal Area 5d. Neuron, 75 (2). pp. 342-351. ISSN 0896-6273. PMCID PMC3408621. doi:10.1016/j.neuron.2012.03.041. https://resolver.caltech.edu/CaltechAUTHORS:20120925-091629158

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Abstract

Competing models of sensorimotor computation predict different topological constraints in the brain. Some models propose population coding of particular reference frames in anatomically distinct nodes, whereas others require no such dedicated subpopulations and instead predict that regions will simultaneously code in multiple, intermediate, reference frames. Current empirical evidence is conflicting, partly due to difficulties involved in identifying underlying reference frames. Here, we independently varied the locations of hand, gaze, and target over many positions while recording from the dorsal aspect of parietal area 5. We find that the target is represented in a predominantly hand-centered reference frame here, contrasting with the relative code seen in dorsal premotor cortex and the mostly gaze-centered reference frame in the parietal reach region. This supports the hypothesis that different nodes of the sensorimotor circuit contain distinct and systematic representations, and this constrains the types of computational model that are neurobiologically relevant.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neuron.2012.03.041DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408621PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2012 Elsevier Inc. Accepted: May 21, 2012. Published: July 25, 2012. This work was supported by National Institutes of Health Grant EY005522. We thank Tessa Yao for editorial assistance, Kelsie Pejsa and Nicole Sammons for animal care, Igor Kagan for magnetic resonance imaging, Viktor Shcherbatyuk for technical assistance, and Bijan Pesaran and Matthew Nelson for helpful discussions.
Funders:
Funding AgencyGrant Number
NIHEY005522
Issue or Number:2
PubMed Central ID:PMC3408621
DOI:10.1016/j.neuron.2012.03.041
Record Number:CaltechAUTHORS:20120925-091629158
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120925-091629158
Official Citation:Lindsay R. Bremner, Richard A. Andersen, Coding of the Reach Vector in Parietal Area 5d, Neuron, Volume 75, Issue 2, 26 July 2012, Pages 342-351, ISSN 0896-6273, 10.1016/j.neuron.2012.03.041. (http://www.sciencedirect.com/science/article/pii/S0896627312005223)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34340
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Sep 2012 16:27
Last Modified:09 Nov 2021 23:07

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