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As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs

Sigal, Alex and Baltimore, David (2012) As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs. Cell Host & Microbe, 12 (2). pp. 132-138. ISSN 1931-3128. doi:10.1016/j.chom.2012.07.005.

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Human immunodeficienty virus (HIV) infection is suppressed but not eliminated by antiretroviral drugs. Viral persistence in the face of therapy has been explained by viral latency, lowered effectiveness of drugs in some anatomical sites and cell types, and cell-to-cell spread. These mechanisms allow for drug-sensitive virus to persist despite treatment. Understanding the persistence mechanism at work at different times after infection, including the time of initial infection immediately following transmission when reservoirs are first formed, will reveal if we are at the limit of what can be achieved with the current therapy paradigm of suppressing ongoing virus replication with drugs. We discuss some of the possible reasons why HIV persists at different points on the infection timeline, focusing on the role ongoing replication may have in maintaining the infection despite drugs at early times postexposure.

Item Type:Article
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URLURL TypeDescription
Sigal, Alex0000-0001-8571-2004
Baltimore, David0000-0001-8723-8190
Additional Information:© 2012 Elsevier Inc. Available online 15 August 2012. A.S. was supported by the Human Frontiers Long Term Fellowship LT00946. This work was supported by amfAR award 108292-51-RGRL.
Funding AgencyGrant Number
Human Frontiers Science Program (HFSP)LT00946
American Foundation for AIDS Research108292-51-RGRL
Issue or Number:2
Record Number:CaltechAUTHORS:20120927-115842334
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Official Citation:Alex Sigal, David Baltimore, As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs, Cell Host & Microbe, Volume 12, Issue 2, 16 August 2012, Pages 132-138, ISSN 1931-3128, 10.1016/j.chom.2012.07.005. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34504
Deposited By: Aucoeur Ngo
Deposited On:27 Sep 2012 22:29
Last Modified:09 Nov 2021 23:08

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