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Formation and migration of neural crest cells in the vertebrate embryo

Bronner, Marianne E. (2012) Formation and migration of neural crest cells in the vertebrate embryo. Histochemistry and Cell Biology, 138 (2). pp. 179-186. ISSN 0948-6143. PMCID PMC3425661. doi:10.1007/s00418-012-0999-z. https://resolver.caltech.edu/CaltechAUTHORS:20120928-095223938

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Abstract

The neural crest is a stem cell population, unique to vertebrates, that gives rise to a vast array of derivatives, ranging from peripheral ganglia to the facial skeleton. This population is induced in the early embryo at the border of the neural plate, which will form the central nervous system (CNS). After neural tube closure, neural crest cells depart from the dorsal CNS via an epithelial to mesenchymal transition (EMT), forming a migratory mesenchymal cell type that migrates extensive to diverse locations in the embryo. Using in vivo loss-of-function approaches and cis-regulatory analysis coupled with live imaging, we have investigated the gene regulatory network that mediates formation of this fascinating cell type. The results show that a combination of transcriptional inputs and epigenetic modifiers control the timing of onset of neural crest gene expression. This in turn leads to the EMT process that produces this migratory cell population.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s00418-012-0999-zDOIArticle
http://www.springerlink.com/content/u2vw7383222l1854/PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425661/PubMed CentralArticle
ORCID:
AuthorORCID
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2012 Springer-Verlag. Accepted: 20 June 2012; Published online: 22 July 2012. Robert Feulgen Lecture presented at the 54th Symposium of the Society for Histochemistry in Vienna, Austria, 5–8 September 2012. This work was partially supported by NIH Grant HD037105 to MEB. I thank Drs. Marcos Simoes-Costa, Shuyi Nie, and Pablo Strobl-Mazzulla for providing figures.
Funders:
Funding AgencyGrant Number
NIHHD037105
Subject Keywords:Neural crest; Neural tube; EMT; Transcription factor; Chromatin; Cis-regulatory network
Issue or Number:2
PubMed Central ID:PMC3425661
DOI:10.1007/s00418-012-0999-z
Record Number:CaltechAUTHORS:20120928-095223938
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120928-095223938
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34537
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Sep 2012 18:32
Last Modified:09 Nov 2021 23:09

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